| Expression pattern: |
UP |
| Associated gene: |
SKA2, Ago2 |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
Promotes breast cancer cell proliferation, migration and invasion, inhibits apoptosis, and promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-136-5p to increase SKA2 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0001387 expression is associated with poorer prognosis in BC patients. |
| Description: |
circ_0001387 is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-136-5p, thereby relieving repression of SKA2 and promoting tumor growth in a cell line-derived xenograft model; high circ_0001387 correlates with poorer prognosis. |
| Confidence score: |
0.8592 |