| Expression pattern: |
UP |
| Associated gene: |
NFIB |
| Associated microRNA: |
miR-139-5p |
| Biological function: |
CircIQCH functions as an oncogene in breast cancer; it promotes BC cell growth, colony formation, cell cycle progression, migration, invasion, metastasis, autophagy, and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
CircIQCH acts through a ceRNA mechanism by sponging miR-139-5p to positively regulate NFIB expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); autophagy (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircIQCH may be a novel therapeutic target for breast cancer. |
| Description: |
CircIQCH is up-regulated in breast cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes malignant breast cancer phenotypes and tumor growth by sponging miR-139-5p and elevating NFIB expression, thereby enhancing proliferation, metastasis-related behaviors, cell cycle progression, and autophagy while suppressing apoptosis. |
| Confidence score: |
0.7052 |