circRNA basic information
circBase ID: hsa_circ_0035445
Name: hsa_circ_ALDH1A2
Synonym: -
Host Gene: ALDH1A2
Genomic location(hg19): chr15:58302846-58306479:-
Genomic location(hg38): chr15:58010648-58014281:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; paired non-cancer tissues; plasma
Cell lines:

GES-1; MGC-803; SGC-7901; AGS; BGC-823; HGC-27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Suppresses proliferation and migration, promotes apoptosis, and induces G0/G1 arrest in gastric cancer cells.
Molecular mechanism: -
Biological pathway or process:

proliferation (inhibits); migration (inhibits); apoptosis (promotes); cell cycle (inhibits)
Detected method:
Q
Validation methods:

divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay
Clinical significance:

Potential diagnostic biomarker in tissues and plasma (AUC 0.68 in tissues; 0.86 in plasma; combined 0.88); tissue expression associated with tumor size and distant metastasis; plasma levels associated with CEA, CA19-9, and lymph node metastasis.
Description:

hsa_circ_0035445 is down-regulated in gastric cancer tissues, patient plasma, and most gastric cancer cell lines. Functionally, increasing hsa_circ_0035445 inhibits proliferation and migration, promotes apoptosis, and induces G0/G1 arrest, supporting a tumor-suppressor role and potential diagnostic utility (ROC/AUC in tissue and plasma).
Confidence score:

0.737
Other information
Title:

Tumor suppressor role of hsa_circ_0035445 in gastric cancer.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 33830559
Study type:

combined biological and clinical study
Data availability: All data are included in this article.
Code availability: -