| Expression pattern: |
UP |
| Associated gene: |
HMGB1, Ago2 |
| Associated microRNA: |
miR-34a-5p, miR-431-5p |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, and invasion. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-34a-5p and miR-431-5p to increase HMGB1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ0036602 expression correlated with clinicopathologic characteristics and shorter patient survival (poor prognosis). |
| Description: |
circ0036602 is upregulated in HPV-16 positive cervical cancer and promotes proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA sponging miR-34a-5p and miR-431-5p to derepress HMGB1, and high circ0036602 is associated with poorer survival. |
| Confidence score: |
0.853 |