| Expression pattern: |
UP |
| Associated gene: |
KIF2C, KIF18B, MELK, BIRC5, PLK1, CKAP2L |
| Associated microRNA: |
miR-520f, miR-1261, miR-1270, miR-620, miR-188-3p, miR-516b, miR-940, miR-661 |
| Biological function: |
Promotes proliferation, migration and invasion in LAC cells. |
| Molecular mechanism: |
May act as a miRNA sponge within a circRNA-miRNA-mRNA (ceRNA) network to regulate hub genes (e.g., miR-1270/MELK and miR-1261/BIRC5). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay |
| Clinical significance: |
Higher expression level indicates poorer prognosis in patients with LAC. |
| Description: |
hsa_circ_0072088 is up-regulated in lung adenocarcinoma and higher expression is associated with poorer prognosis. Its knockdown inhibits LAC cell proliferation, migration, and invasion, and network analysis suggests a potential ceRNA axis involving miR-1270/MELK and miR-1261/BIRC5. |
| Confidence score: |
0.7842 |