| Expression pattern: |
UP |
| Associated gene: |
KIF20A, AGO2 |
| Associated microRNA: |
miR-153-3p |
| Biological function: |
Promotes cervical cancer cell growth, colony formation, proliferation, migration, invasion, metastasis and tumor growth in vivo. |
| Molecular mechanism: |
circ_0005576 is mainly cytoplasmic and acts as a ceRNA sponge for miR-153-3p, thereby increasing KIF20A expression and promoting cervical cancer progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0005576 expression is associated with advanced FIGO stage, lymph node metastasis and poor overall survival in cervical cancer patients. |
| Description: |
circ_0005576 is upregulated in cervical cancer tissues and cell lines and its high expression is associated with advanced FIGO stage, lymph node metastasis and poor overall survival. Functionally, circ_0005576 promotes cervical cancer cell proliferation, migration, invasion and in vivo tumor growth. Mechanistically, it is mainly cytoplasmic and promotes KIF20A expression by sponging miR-153-3p. |
| Confidence score: |
0.8226 |