| Expression pattern: |
UP |
| Associated gene: |
PIK3CA, Ago2 |
| Associated microRNA: |
miR-1261 |
| Biological function: |
enhances cell proliferation, migration, and invasion |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_0072088 sponges miR-1261 to relieve repression of PIK3CA |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); PI3K/AKT/mTOR (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Sanger Sequencing; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0072088 is up-regulated in LUAD tissues/cells and mainly localized in the cytoplasm. It promotes LUAD cell proliferation, migration and invasion by acting as a ceRNA sponge for miR-1261, thereby increasing PIK3CA expression (circ_0072088/miR-1261/PIK3CA axis). |
| Confidence score: |
0.8267 |