| Expression pattern: |
UP |
| Associated gene: |
MECP2 |
| Associated microRNA: |
miR-1324 |
| Biological function: |
promotes proliferation and invasion of lung adenocarcinoma cells; enhances invasiveness and proliferative capacity |
| Molecular mechanism: |
ceRNA mechanism: circ-PRKCI binds microRNA-1324 and promotes MECP2 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
high expression predicts poor prognosis of LCa patients; potential therapeutic target |
| Description: |
circ-PRKCI is up-regulated in lung cancer/lung adenocarcinoma tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circ-PRKCI promotes proliferation and invasion of lung adenocarcinoma cells. Mechanistically, it mainly acts as a cytoplasmic ceRNA by binding microRNA-1324 to promote MECP2 expression. |
| Confidence score: |
0.7357 |