circRNA basic information
circBase ID: -
Name: hsa_circ_AURKA
Synonym: -
Host Gene: AURKA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002477
MONDO name: prostate neuroendocrine neoplasm
Disease details: neuroendocrine prostate cancer
Disease DO ID:
 2992
Disease MeSH ID:
 -
Disease NCIt ID:
 C5545
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

NCI-H660; LNCaP; VCaP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with neuroendocrine differentiation subtype; higher expression in NEPC and in the NEPC cell line NCI-H660 compared to non-NEPC prostate cancer cell lines.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation
Clinical significance:

Potential surrogate marker to distinguish neuroendocrine prostate cancer subtype.
Description:

circ-AURKA is significantly up-regulated in neuroendocrine prostate cancer compared with CRPC. Its circular structure and backsplice (exon 6 to exon 3) were confirmed by RT-qPCR after RNase R treatment, and it shows higher expression in the NEPC cell line NCI-H660 than in non-NEPC prostate cancer cell lines.
Confidence score:

0.4773
Other information
Title:

The Landscape of Circular RNA in Cancer.

Journal: Cell
Published: 2019
PubMed ID: 30735636
Study type:

combined biological and clinical study
Data availability: https://mioncocirc.github.io/; https://mioncocirc.github.io/download/; dbGaP (phs000673.v2.p1); dbGaP (phs000915.v1.p1); dbGaP (phs000673.v1.p1)
Code availability: https://github.com/mcieslik-mctp/codac