| Expression pattern: |
UP |
| Associated gene: |
GSTM5, AKT, mTOR |
| Associated microRNA: |
miR-20b-3p |
| Biological function: |
Promotes CRC cell proliferation, migration, and invasion; facilitates CRC progression. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-20b-3p to regulate GSTM5 and downstream AKT-mTOR signaling. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); PI3K/AKT/mTOR (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
Diagnostic value for CRC (AUC 0.806) and higher diagnostic performance in advanced-stage CRC. |
| Description: |
circ_0084927 is up-regulated in colorectal cancer and promotes CRC cell proliferation, migration and invasion. It functions as a ceRNA by sponging miR-20b-3p to upregulate GSTM5 and activate the AKT/mTOR pathway, supporting CRC progression and showing diagnostic potential. |
| Confidence score: |
0.7113 |