| Expression pattern: |
UP |
| Associated gene: |
TLN1 |
| Associated microRNA: |
miR-1285-3p |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circRNA_400029 sponges miR-1285-3p to regulate TLN1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (other); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
circRNA_400029 expression was closely related to histology, tumor differentiation, and TNM stage |
| Description: |
circRNA_400029 is up-regulated in cervical cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis, acting as a ceRNA that sponges miR-1285-3p to de-repress TLN1. |
| Confidence score: |
0.7034 |