| Expression pattern: |
UP |
| Associated gene: |
CENPF |
| Associated microRNA: |
miR‐508‐3p |
| Biological function: |
Promotes breast cancer cell proliferation, migration, invasion, metastasis and EMT, and suppresses apoptosis; its knockdown inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-508-3p, thereby up-regulating CENPF. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
Higher hsa_circ_0002082 expression (in tissues and plasma) was closely related to advanced TNM stages and lymph node metastasis. |
| Description: |
In breast cancer, hsa_circ_0002082 is up-regulated in tumors and patient plasma and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, metastasis and EMT) and inhibits apoptosis by sponging miR-508-3p to up-regulate CENPF; silencing hsa_circ_0002082 suppresses xenograft growth. |
| Confidence score: |
0.7791 |