circRNA basic information
circBase ID: hsa_circ_0000515
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: RPPH1
Genomic location(hg19): chr14:20811305-20811534:-
Genomic location(hg38): chr14:20343146-20343375:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC samples
Cell lines:

Caco-2; HCT-116; HT-29; SW-480; SW-620; DLD-1; NCM-460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NCAM1, CD44, SYP, NCAPG, WNT5A, POLA1, ZC3H10, SAMD4A, ENOX1
Associated microRNA: hsa-miR-296-5p, hsa-miR-1976, hsa-miR-1306-5p, hsa-miR-326, hsa-miR-1296-5p
Biological function: Associated with CRC immunoregulatory ceRNA and circRNA-protein (RBP) networks linked to macrophage infiltration (functional role not experimentally validated).
Molecular mechanism: Predicted ceRNA interactions via multiple miRNAs to hub mRNAs; predicted binding to immune-related proteins (ZC3H10, SAMD4A, ENOX1).
Biological pathway or process:

ceRNA regulation (other); immune regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

Potential diagnostic and therapeutic paradigm for CRC (no circRNA-specific clinical endpoint reported).
Description:

hsa_circ_0000515 is a co-upregulated RPPH1-derived circRNA in CRC. It participates in the predicted ceRNA subnetwork through multiple miRNAs (including hsa-miR-326 and hsa-miR-1296-5p) to hub genes (e.g., WNT5A, POLA1), and is also predicted to bind immune-related RBPs/proteins including ZC3H10, SAMD4A and ENOX1. Its expression is detected by qRT-PCR in a subset of CRC cell lines.
Confidence score:

0.4032
Other information
Title:

Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 35155186
Study type:

combined biological and clinical study
Data availability: GSE126094; https://www.frontiersin.org/articles/10.3389/fonc.2021.779706/full#supplementary-material
Code availability: -