circRNA basic information
circBase ID: -
Name: hsa_circ_SATB1
Synonym: circ-SATB1
Host Gene: SATB1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008433
MONDO name: small cell lung carcinoma
Disease details: small cell lung cancer / SCLC
Disease DO ID:
 5409, 5411
Disease MeSH ID:
 D055752
Disease NCIt ID:
 C4917
Disease ICD11 ID:
 1800431439
Disease OMIM ID:
 182280
Species: Human
Species details: Homo sapiens
Tissue specimen:

SCLC tissues; adjacent noncancerous lung tissues; NSCLC tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for SCLC, especially in combination with circ-STXBP5L; not differentially expressed in NSCLC tissues.
Molecular mechanism: Not experimentally characterized for this circRNA in this study.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circ-STXBP5L alone or coupled with circ-SATB1 may potentially help distinguish between SCLC and NSCLC for diagnosis.
Description:

circ-SATB1 was identified and qRT-PCR validated as upregulated in most SCLC tissues. Unlike several other upregulated circRNAs, it was not altered in NSCLC, and the authors proposed that it may complement circ-STXBP5L for distinguishing SCLC from NSCLC.
Confidence score:

0.4685
Other information
Title:

RNA-Seq profiling of circular RNAs in human small cell lung cancer.

Journal: Epigenomics
Published: 2020
PubMed ID: 32079426
Study type:

combined biological and clinical study
Data availability: Supplementary Table 1; Supplementary Table 2; Supplementary Table 3; www.futuremedicine.com/doi/suppl/10.2217/epi-2019-0382
Code availability: https://github.com/bioxfu/circRNAFinder