circRNA basic information
circBase ID: hsa_circ_0091581
Name: hsa_circ_GPC3
Synonym: circ_0091581
Host Gene: GPC3
Genomic location(hg19): chrX:132887508-132888203:-
Genomic location(hg38): chrX:133753481-133754176:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissue; adjacent nonneoplastic tissue
Cell lines:

U138; U87; U251; A172; T98G
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: RMI1 / Ago2
Associated microRNA: miR-1243-5p
Biological function: promotes proliferation, migration, and invasion of glioma cells; promotes glioma growth in vivo
Molecular mechanism: ceRNA mechanism: hsa_circ_0091581 sponges miR-1243-5p to regulate RMI1 in a miR-1243-5p-dependent manner
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0091581 is up-regulated in glioma tissues and cell lines and promotes glioma cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-1243-5p to increase RMI1, and its knockdown suppresses tumor growth in a U87 xenograft model.
Confidence score:

0.7792
Other information
Title:

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p.

Journal: Journal of Cancer
Published: 2021
PubMed ID: 33976734
Study type:

combined biological and clinical study
Data availability: -
Code availability: -