| Expression pattern: |
UP |
| Associated gene: |
CDK6 |
| Associated microRNA: |
miR-646 |
| Biological function: |
Promotes GC cell proliferation and invasion and promotes cisplatin resistance; silencing inhibits tumor growth in vivo and enhances cisplatin inhibitory effects. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-646 to upregulate CDK6, contributing to GC progression and cisplatin resistance. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0081143 expression was associated with advanced TNM stage, lymphnode metastases, and poor overall survival of GC patients. |
| Description: |
hsa_circ_0081143 is up-regulated in gastric cancer and correlates with advanced clinical features and poor overall survival. Functionally, it promotes proliferation/invasion and cisplatin resistance. Mechanistically, it sponges miR-646 to relieve repression of CDK6, thereby supporting GC progression. |
| Confidence score: |
0.8353 |