circRNA basic information
circBase ID: hsa_circ_0004674
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr7:87593948-87607727:+
Genomic location(hg38): chr7:87964633-87978412:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent tissues; serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ABCC2, EGFR
Associated microRNA: miR-490-3p, miR-1254
Biological function: Associated with lung metastasis and chemotherapy resistance; high serum expression indicates higher risk of metastasis and poor response to chemotherapy.
Molecular mechanism: Not experimentally investigated in this study; discussion cites possible ceRNA axes involving miR-490-3p/ABCC2 and miR-1254/EGFR.
Biological pathway or process:

chemoresistance (other); metastasis (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

Upregulated in tumor tissues and serum; associated with lung metastasis and chemotherapy resistance; higher serum expression predicts worse progression-free survival; contributes to ROC-based prediction of chemosensitivity and metastasis.
Description:

In 20 conventional osteosarcoma patients, hsa_circ_0004674 was significantly upregulated in tumor tissue and serum. Higher serum hsa_circ_0004674 was associated with lung metastasis, chemoresistance, and worse progression-free survival, supporting its use (alone and combined with OIP5-AS1) as a clinical biomarker.
Confidence score:

0.4758
Other information
Title:

Combination of hsa_circ_0004674 and lncRNA OIP5‑AS1 as a novel clinical biomarker used to predict prognosis in patients with osteosarcoma.

Journal: Experimental and therapeutic medicine
Published: 2023
PubMed ID: 37090082
Study type:

clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -