| Expression pattern: |
DN |
| Associated gene: |
FOXO1, LEPR |
| Associated microRNA: |
miR-96-5p |
| Biological function: |
Inhibits tumor progression in HCC. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-96-5p and promote FOXO1 expression (hsa_circ_0039466/miR-96-5p/FOXO1 network). |
| Biological pathway or process: |
insulin resistance (other); AMPK (other); ceRNA regulation (other); proliferation (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation |
| Clinical significance: |
Closely related to clinical stage; lower hsa_circ_0039466 expression in advanced stages (III+IV, BCLC C, T3+T4). |
| Description: |
This study identifies hsa_circ_0039466 as down-regulated in HCC tissues and proposes a ceRNA mechanism in which hsa_circ_0039466 sponges miR-96-5p to facilitate FOXO1 expression, thereby inhibiting tumor progression. The axis is associated with clinical stage and is linked by enrichment analysis to insulin resistance/insulin metabolism-related pathways. |
| Confidence score: |
0.4032 |