circRNA basic information
circBase ID: hsa_circ_0077837
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:131247744-131277639:-
Genomic location(hg38): chr6:130926604-130956499:-
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancer tissues; paired non-cancer tissues; non-tumor tissues; primary tumors
Cell lines:

HCC827
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: -
Biological function: Suppresses NSCLC cell apoptosis (oncogenic role).
Molecular mechanism: hsa_circ_0077837 increases PTEN gene methylation, downregulating PTEN expression, thereby reducing apoptosis.
Biological pathway or process:

apoptosis (inhibits); PI3K/AKT (other); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; MSP (Methylation-Specific PCR); Western Blot; Annexin V/PI Flow Cytometry
Clinical significance:

High hsa_circ_0077837 levels in cancer tissues predict poor survival of NSCLC patients and are higher in advanced stages (III+IV) than early stages (I+II).
Description:

hsa_circ_0077837 is upregulated in NSCLC tissues and is associated with worse patient survival. In HCC827 cells, hsa_circ_0077837 overexpression increases PTEN gene methylation and reduces PTEN expression, thereby suppressing apoptosis; PTEN overexpression counteracts this effect.
Confidence score:

0.7328
Other information
Title:

Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation.

Journal: Bioengineered
Published: 2022
PubMed ID: 35246018
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -