| Expression pattern: |
DN |
| Associated gene: |
CDK2AP2 |
| Associated microRNA: |
miR-4664-3p |
| Biological function: |
Suppresses proliferation and migration; induces G0/G1 phase arrest; suppresses xenograft tumor growth and angiogenesis |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-4664-3p to upregulate CDK2AP2, modulating p53/p21/p27 and CDK2/cyclin E1 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); cell cycle (inhibits); apoptosis (unclear); p53 signaling (promotes); angiogenesis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circ-36683 expression is decreased in NSCLC tissues vs paracarcinoma and negatively correlates with miR-4664-3p expression |
| Description: |
hsa_circ_0036683 (circ-36683), a circRNA derived from ABHD2, is down-regulated in NSCLC tissues and lung cancer cell lines. It mainly localizes to the cytoplasm and suppresses NSCLC cell proliferation, migration, and xenograft growth by sponging miR-4664-3p to relieve repression of CDK2AP2, thereby promoting p53/p21/p27 and inhibiting CDK2/cyclin E1 to induce G0/G1 arrest. |
| Confidence score: |
0.8521 |