| Expression pattern: |
DN |
| Associated gene: |
AGO2 protein, RNF128 / ring finger protein 128 |
| Associated microRNA: |
miR-581 |
| Biological function: |
suppresses prostate cancer metastasis, migration and invasion; has little effect on PCa cell proliferation |
| Molecular mechanism: |
circPHF16 sponges miR-581 to modulate RNF128 expression and inhibit Wnt/beta-catenin signaling, thereby suppressing prostate cancer metastasis |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); metastasis (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circPHF16 was downregulated in prostate cancer tissues compared with normal tissues and may be an additional target for metastatic prostate cancer |
| Description: |
circPHF16 is downregulated in prostate cancer and acts as a tumor-suppressive circRNA. It inhibits prostate cancer cell migration, invasion and metastasis by sponging miR-581, upregulating RNF128, and suppressing Wnt/beta-catenin signaling. |
| Confidence score: |
0.8516 |