| Expression pattern: |
UP |
| Associated gene: |
AGO2, beta-catenin, YTHDC1 |
| Associated microRNA: |
miR-495 |
| Biological function: |
circPTK2 promotes TNBC cisplatin resistance, cell viability and invasion, inhibits DDP-induced DNA damage and apoptosis-related responses, and acts as a clinical biomarker for DDP resistance. |
| Molecular mechanism: |
m6A-modified circPTK2 is positively associated with YTHDC1, binds miR-495 through ceRNA activity, relieves miR-495-mediated suppression of beta-catenin, and activates Wnt/beta-catenin signaling to mediate TNBC DDP resistance. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); m6A modification (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; MeRIP / MeRIP-seq; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; TUNEL; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circPTK2 expression is associated with DDP chemotherapy resistance, predicts poorer clinical prognosis, and plasma circPTK2 may serve as a non-invasive biomarker for clinical detection of DDP resistance in TNBC. |
| Description: |
circPTK2 is up-regulated in TNBC cisplatin-resistant cells, tissues, and plasma, and high expression is associated with DDP resistance and poor prognosis. Functionally, circPTK2 promotes chemoresistance, viability, and invasion, while knockdown enhances DDP-induced DNA damage and sensitivity. Mechanistically, m6A/YTHDC1-related circPTK2 acts through a miR-495/beta-catenin/Wnt signaling axis. |
| Confidence score: |
0.9018 |