circRNA basic information
circBase ID: -
Name: hsa_circ_FAM13B
Synonym: circFAM13B
Host Gene: FAM13B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson’s disease / PD
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FAM13B
Associated microRNA: -
Biological function: potential key player in PD pathogenesis; potential biomarker
Molecular mechanism: circRNA and linear transcript both associated; in-silico predicted miRNA binding; pathway enrichment via miRNAs
Biological pathway or process:

Hippo/YAP (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; ROC Analysis
Clinical significance:

part of circRNA diagnostic models for PD and at-risk individuals
Description:

circFAM13B is down-regulated in PD blood and is discussed as a potentially important contributor to PD pathogenesis. The study also notes that both linear and circular forms of FAM13B show independent associations with PD in blood.
Confidence score:

0.348
Other information
Title:

Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.

Journal: NPJ Parkinson's disease
Published: 2024
PubMed ID: 39557914
Study type:

bioinformatics study
Data availability: AMP-PD (https://amp-pd.org/); pdbloodtranscriptomics.wustl.edu
Code availability: https://github.com/Ibanez-Lab/BloodCircularRNA-ParkinsonsDisease