| Expression pattern: |
UP |
| Associated gene: |
MAP3K3, LDLRAD3, AGO2, PCNA, Bax, Bcl-2, Ki67 |
| Associated microRNA: |
miR-491-5p |
| Biological function: |
Circ_0006988 promotes NSCLC cell proliferation, migration, invasion, angiogenesis, metastasis and xenograft tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0006988 functions as a ceRNA/miRNA sponge for miR-491-5p, thereby modulating MAP3K3 expression through the circ_0006988/miR-491-5p/MAP3K3 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; Wound Healing Assay; Tube Formation Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Circ_0006988 may act as a therapeutic target for NSCLC. |
| Description: |
Circ_0006988 is up-regulated in NSCLC tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. Mechanistically, circ_0006988 sponges miR-491-5p to increase MAP3K3 expression, forming a circ_0006988/miR-491-5p/MAP3K3 regulatory axis. |
| Confidence score: |
0.8443 |