| Expression pattern: |
UP |
| Associated gene: |
CEACAM6 |
| Associated microRNA: |
miR-1256 |
| Biological function: |
circ_0008035 promotes GC cell proliferation, migration, invasion, cell cycle progression and tumor growth, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0008035 acts as a ceRNA by sponging miR-1256 to regulate CEACAM6 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0008035 might be a new target for the treatment of GC. |
| Description: |
circ_0008035 is up-regulated in gastric cancer tissues and cells. It promotes malignant phenotypes and tumor growth by sponging miR-1256 and increasing CEACAM6 expression, indicating a potential therapeutic target for GC. |
| Confidence score: |
0.7761 |