circRNA basic information
circBase ID: hsa_circ_0002360
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr21:36206706-36231875:-
Genomic location(hg38): chr21:34834409-34859578:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAC tissues; adjacent normal tissues; tumor tissues; adjacent non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PHF19
Associated microRNA: hsa-mir-3620-5p
Biological function: hsa_circ_0002360 is aberrantly and abundantly expressed in LAC tissues and may participate in the development and pathogenesis of LAC.
Molecular mechanism: Predicted circRNA-miRNA-mRNA regulatory mechanism in which upregulated hsa_circ_0002360 may inhibit hsa-mir-3620-5p and thereby increase PHF19 expression.
Biological pathway or process:

ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
S
Validation methods:

divergent primers PCR; RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis; RNA-seq
Clinical significance:

hsa_circ_0002360 may be a valuable therapeutic target for LAC treatment.
Description:

This study identifies hsa_circ_0002360 as an up-regulated circRNA in human lung adenocarcinoma tissues, validated by qRT-PCR after circRNA sequencing. The authors propose a hsa_circ_0002360/hsa-mir-3620-5p/PHF19 regulatory axis, in which increased hsa_circ_0002360 may suppress hsa-mir-3620-5p and increase PHF19 expression, contributing to LAC pathogenesis and suggesting therapeutic potential.
Confidence score:

0.7352
Other information
Title:

RNA-Seq profiling of circular RNAs and potential function of hsa_circ_0002360 in human lung adenocarcinom.

Journal: American journal of translational research
Published: 2019
PubMed ID: 30787976
Study type:

combined biological and clinical study
Data availability: Table S1; Table S2; Table S3
Code availability: -