circRNA basic information
circBase ID: hsa_circ_0074332
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr5:141004774-141009692:-
Genomic location(hg38): chr5:141625207-141630125:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009688
MONDO name: myasthenia gravis
Disease details: Myasthenia Gravis
Disease DO ID:
 437
Disease MeSH ID:
 D009157
Disease NCIt ID:
 C60989
Disease ICD11 ID:
 1270100227
Disease OMIM ID:
 254200
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NNT, NOVA1, DAB2IP, NRP1, DGKH, PAX5, GTF2I, RNF150, IGF1, RNF217, ZDHHC18
Associated microRNA: hsa-miR-1305, hsa-miR-338-3p
Biological function: identified as an upregulated critical circRNA related to the establishment or maintenance of cell polarity and included in a predicted MG-associated ceRNA network
Molecular mechanism: predicted ceRNA mechanism in a circRNAs-miRNAs-mRNAs regulatory network
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0074332 was identified from microarray data as an upregulated critical circRNA in MG and incorporated into a predicted circRNA-miRNA-mRNA ceRNA network. Unlike hsa_circ_0062400 and hsa_circ_0002397, no in vitro functional validation specific to hsa_circ_0074332 was reported.
Confidence score:

0.348
Other information
Title:

From Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.

Journal: Endocrine, metabolic & immune disorders drug targets
Published: 2026
PubMed ID: 41863473
Study type:

bioinformatics study
Data availability: De-identified processed data and non-privacy-related raw data are available from the corresponding author upon reasonable request and with ethical approval.
Code availability: -