circRNA basic information
circBase ID: hsa_circ_0002397
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:114709055-114713283:+
Genomic location(hg38): chr2:113951478-113955706:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009688
MONDO name: myasthenia gravis
Disease details: Myasthenia Gravis
Disease DO ID:
 437
Disease MeSH ID:
 D009157
Disease NCIt ID:
 C60989
Disease ICD11 ID:
 1270100227
Disease OMIM ID:
 254200
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Jurkat
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NRP1
Associated microRNA: hsa-miR-1305, hsa-miR-338-3p, miR-338-3p
Biological function: modulates NRP1 expression and Jurkat cell proliferation; silencing suppresses NRP1 expression and Jurkat cell viability
Molecular mechanism: ceRNA mechanism; sponging miR-338-3p to regulate NRP1
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); immune regulation (other); inflammation (promotes); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; RT-qPCR; Western Blot; CCK8
Clinical significance:

provided potential treatment targets for MG
Description:

hsa_circ_0002397 was identified as an upregulated circRNA in MG samples and was functionally validated in Jurkat cells. It appears to promote NRP1 expression and Jurkat cell proliferation by sponging miR-338-3p, implicating a hsa_circ_0002397/miR-338-3p/NRP1 ceRNA axis in MG pathogenesis.
Confidence score:

0.6676
Other information
Title:

From Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.

Journal: Endocrine, metabolic & immune disorders drug targets
Published: 2026
PubMed ID: 41863473
Study type:

combined biological and clinical study
Data availability: De-identified processed data and non-privacy-related raw data are available from the corresponding author upon reasonable request and with ethical approval.
Code availability: -