| Expression pattern: |
UP |
| Associated gene: |
HSP90 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
promotes non-small cell lung cancer cell proliferation, migration and invasion |
| Molecular mechanism: |
circHIPK2 targets miR-485-5p and regulates HSP90 expression/function; miR-485-5p induces HSP90 ubiquitination to impede circHIPK2-associated NSCLC cell proliferation |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other); ubiquitination (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Western Blot |
| Clinical significance: |
circHIPK2 is up-regulated in NSCLC tissues, higher in stage III-IV patients, and high expression is associated with lower overall survival rate and disease-free survival rate |
| Description: |
circHIPK2 is up-regulated in NSCLC tissues and cell lines, with higher expression associated with advanced stage and worse OS/DFS. Functionally, circHIPK2 promotes NSCLC cell proliferation, migration and invasion, likely through suppressing miR-485-5p and regulating HSP90 expression/function and ubiquitination. |
| Confidence score: |
0.7523 |