circRNA basic information
circBase ID: hsa_circ_0007031
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr13:113158345-113181798:-
Genomic location(hg38): chr13:112504031-112527484:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

clinical tissues; tumor tissues
Cell lines:

HCT116; SW480; HCT116/5-FU; SW480/5-FU
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ABCC5, Ago2, Cyclin D1, Ki67, MMP9, Snail
Associated microRNA: miR-133b
Biological function: circ_0007031 promotes CRC cell survival, proliferation, colony formation, migration, invasion, tumor growth in vivo, and 5-FU resistance; circ_0007031 knockdown suppresses malignant progression and enhances 5-FU sensitivity.
Molecular mechanism: circ_0007031 acts as a miR-133b sponge to regulate ABCC5 expression, thereby promoting CRC progression and 5-FU resistance.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (promotes); chemoresistance (promotes); drug resistance (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circ_0007031 up-regulation was associated with CRC resistance to 5-FU.
Description:

circ_0007031 is up-regulated in 5-FU-resistant CRC tissues and cells and is associated with CRC resistance to 5-FU. Functionally, circ_0007031 promotes CRC cell proliferation, migration, invasion, tumor growth, and chemoresistance. Mechanistically, circ_0007031 sponges miR-133b to regulate ABCC5 expression, forming a circ_0007031/miR-133b/ABCC5 axis that contributes to malignant progression and 5-FU resistance.
Confidence score:

0.7277
Other information
Title:

Circ_0007031 enhances tumor progression and promotes 5-fluorouracil resistance in colorectal cancer through regulating miR-133b/ABCC5 axis.

Journal: Cancer biomarkers : section A of Disease markers
Published: 2020
PubMed ID: 32865180
Study type:

combined biological and clinical study
Data availability: -
Code availability: starBase v.3 software (http://starbase.sysu.edu.cn/)