| Expression pattern: |
UP |
| Associated gene: |
RAB1B |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes sorafenib chemoresistance, proliferation, migration and invasion; inhibits apoptosis in sorafenib-resistant HCC cells |
| Molecular mechanism: |
circ_RBM23 acts through a circ_RBM23/miR-338-3p/RAB1B regulatory axis, interacting with miR-338-3p and modulating RAB1B expression |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_RBM23 expression was associated with sorafenib resistance in HCC patients |
| Description: |
circ_RBM23 is up-regulated in sorafenib-resistant HCC tissues and cells. Its knockdown sensitizes resistant HCC cells to sorafenib, suppresses proliferation, migration and invasion, increases apoptosis, and delays xenograft tumor growth. Mechanistically, circ_RBM23 promotes sorafenib resistance and malignant phenotypes through the miR-338-3p/RAB1B axis. |
| Confidence score: |
0.8175 |