circRNA basic information
circBase ID: hsa_circ_0000711
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:68155889-68160513:+
Genomic location(hg38): chr16:68121986-68126610:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

Bel-7402; HEK293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: target genes / mRNAs
Associated microRNA: miR-103a-3p
Biological function: promotes proliferation of hepatoma cells and represses apoptosis of hepatoma cells
Molecular mechanism: hsa_circ_0000711 directly binds to has-miR-103a-3p and acts as a molecular sponge in a circRNA-miRNA-mRNA regulatory network
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); MAPK (other); PI3K/AKT/mTOR (other); TGF-beta/SMAD (other); Hippo/YAP (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry
Clinical significance:

-
Description:

This study identified hsa_circ_0000711 as differentially and lowly expressed in HCC tumor tissues based on microarray screening and RT-qPCR validation. Functionally, hsa_circ_0000711 promoted hepatoma cell proliferation and inhibited apoptosis. Mechanistically, it was reported to bind has-miR-103a-3p as a molecular sponge within a circRNA-miRNA-mRNA regulatory network, with predicted involvement in cell cycle and tumor-related signaling pathways.
Confidence score:

0.6777
Other information
Title:

Effects of hsa_circ_0000711 expression level on proliferation and apoptosis of hepatoma cells.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32373952
Study type:

combined biological and clinical study
Data availability: -
Code availability: -