| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-526b-5p, hsa-miR-623, hsa-miR-206, hsa-miR-29b-2-5p |
| Biological function: |
unknown |
| Molecular mechanism: |
predicted miRNA sponge (circRNA-miRNA-mRNA network) |
| Biological pathway or process: |
MAPK (other); PI3K/AKT (other); lipid metabolism (other); cell cycle (other); p53 signaling (other); apoptosis (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic metabolic biomarker for PCa |
| Description: |
The novel circRNA hsa_circ_AKAP7 is up-regulated in prostate cancer tissues and was validated by qRT-PCR. It is computationally linked to a circRNA-miRNA-mRNA regulatory network and PCa-relevant pathways (MAPK, PI3K/AKT, lipid-related processes), suggesting possible metabolic biomarker potential. |
| Confidence score: |
0.4032 |