circRNA basic information
circBase ID: hsa_circ_0059960
Name: hsa_circ_ITCH
Synonym: -
Host Gene: ITCH
Genomic location(hg19): chr20:33065576-33069011:+
Genomic location(hg38): chr20:34477771-34481206:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissue; adjacent normal tissue (ANT)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ITCH
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted ceRNA network linking candidate circRNAs, target miRNAs and the mRNAs of host genes.
Biological pathway or process:

ubiquitination (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0059960 (host gene ITCH) is a key candidate circRNA from the ubiquitin mediated proteolysis-associated set and is validated by qRT-PCR as down-regulated in HPV-16 mediated SCC and ADC tissues compared with adjacent normal tissues. It was incorporated into a predicted circRNA-miRNA-mRNA (ceRNA) network centered on host genes.
Confidence score:

0.5135
Other information
Title:

Comprehensive profile and contrastive analysis of circular RNA expression in cervical squamous carcinoma and adenocarcinoma.

Journal: PeerJ
Published: 2023
PubMed ID: 36721776
Study type:

combined biological and clinical study
Data availability: NCBI’s Gene Expression Omnibus (GEO) (accession number not provided in text)
Code availability: -