| Expression pattern: |
UP |
| Associated gene: |
ZNF90 |
| Associated microRNA: |
miR-6809-3p |
| Biological function: |
promotes proliferation and migration/invasion; suppresses apoptosis; facilitates in vivo tumor growth; promotes EMT |
| Molecular mechanism: |
ceRNA mechanism: circMRPL35 sponges miR-6809-3p to de-repress ZNF90, affecting EMT and TGF-beta1/SMAD2/3 signaling |
| Biological pathway or process: |
EMT (promotes); TGF-beta/SMAD (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; IF (Immunofluorescence); Luciferase Reporter Assay; In Vivo Animal Model; ELISA |
| Clinical significance: |
correlating with lymphatic metastasis and tumor size; potential biomarker for GC |
| Description: |
circMRPL35 is upregulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, migration/invasion, EMT, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-6809-3p to increase ZNF90, thereby activating the TGF-beta1/SMAD2/3 signaling axis. |
| Confidence score: |
0.8072 |