| Expression pattern: |
UP |
| Associated gene: |
circOGDH-cUEP, RPB1, ADAR2, WT1 |
| Associated microRNA: |
- |
| Biological function: |
CircOGDH is an upregulated circ-cUEP candidate during LUAD progression; knockdown reduced LUAD cell proliferation, and its blood level contributed to biomarker performance for LUAD progression. |
| Molecular mechanism: |
CircOGDH is classified as a circ-cUEP that encodes a corresponding cUEP and is positively regulated by RPB1-driven transcriptional programs and negatively regulated by ADAR2-mediated circRNA biogenesis suppression; detailed downstream mechanism was not defined. |
| Biological pathway or process: |
proliferation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
CircOGDH was detectable in peripheral blood and elevated in SN LUAD patients compared with GGO patients; combined measurement with circRIPK1 and circGCN1 improved predictive accuracy for LUAD progression. |
| Description: |
CircOGDH is a human circ-cUEP candidate upregulated during LUAD progression. The study supports a role in promoting LUAD cell proliferation and suggests utility as a peripheral blood biomarker when combined with circRIPK1 and circGCN1, although its detailed downstream mechanism was not resolved. |
| Confidence score: |
0.6987 |