| Expression pattern: |
UP |
| Associated gene: |
PDGFRA, PDGFRB, PDGFRA/B, CXCL1, CXCL3 |
| Associated microRNA: |
miR-1286 |
| Biological function: |
Promotes TNBC progression, cell proliferation, migration and invasion; regulates MDSC differentiation and chemotaxis and contributes to MDSC-mediated immunosuppression. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0006466 sponges miR-1286 to derepress PDGFRA/PDGFRB, affecting PDGF signaling, CXCL1/CXCL3 chemokine secretion and MDSC recruitment. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); immune regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; RNA Pull-Down; CCK8; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle） |
| Clinical significance: |
hsa_circ_0006466 was upregulated in TNBC patients and positively correlated with MDSC abundance; targeting the hsa_circ_0006466-miR-1286-PDGFRA/B axis may suppress TNBC aggressiveness and reverse immune evasion. |
| Description: |
hsa_circ_0006466 is upregulated in TNBC and positively correlates with MDSC abundance. It functions as a ceRNA that sponges miR-1286 to increase PDGFRA/PDGFRB expression, thereby promoting TNBC cell proliferation, migration, invasion and MDSC-mediated immune suppression. The study suggests that targeting this axis may provide a therapeutic strategy for TNBC. |
| Confidence score: |
0.6996 |