| Expression pattern: |
UP |
| Associated gene: |
SMURF1, p-AKT, Bcl-2, Bax |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
circ-NRIP1 promotes CRC cell malignant behavior, including clonogenicity, migration and invasion, reduces 5-FU sensitivity, and inhibits apoptosis through AKT pathway activation. |
| Molecular mechanism: |
circ-NRIP1 competitively binds miR-195-5p, relieves miR-195-5p-mediated suppression of SMURF1, activates the AKT pathway, inhibits apoptosis, and decreases 5-FU sensitivity; curcumin enhances 5-FU sensitivity by downregulating circ-NRIP1. |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
The circ-NRIP1/miR-195-5p/SMURF1/AKT axis may provide a novel strategic approach for clinical CRC treatment by modulating 5-FU sensitivity. |
| Description: |
In CRC cells, circ-NRIP1 is up-regulated and functions as a pro-malignant circRNA that promotes clonogenicity, migration and invasion while reducing sensitivity to 5-FU. Curcumin downregulates circ-NRIP1, thereby strengthening miR-195-5p-mediated inhibition of SMURF1, suppressing AKT pathway activation, promoting apoptosis, and enhancing 5-FU sensitivity. |
| Confidence score: |
0.6542 |