| Expression pattern: |
UP |
| Associated gene: |
FUS |
| Associated microRNA: |
- |
| Biological function: |
Promotes cervical cancer cell proliferation, migration, invasion, tumor formation and metastasis; knockdown suppresses proliferation and invasion and affects cell cycle progression. |
| Molecular mechanism: |
circRNA_0000285 enhances cervical cancer development and metastasis by up-regulating FUS; FUS expression is positively correlated with circRNA_0000285 expression in CC tissues. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); cell cycle (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circRNA_0000285 could be used as a prospective therapeutic target for cervical cancer. |
| Description: |
circRNA_0000285 is up-regulated in cervical cancer tissues and cell lines. Functional knockdown experiments indicate that it promotes CC cell proliferation, migration, invasion, tumor formation and metastasis. Mechanistically, the study links circRNA_0000285 to up-regulation of FUS, suggesting a circRNA_0000285/FUS oncogenic mechanism and potential therapeutic value. |
| Confidence score: |
0.5434 |