| Expression pattern: |
UP |
| Associated gene: |
LRP6 |
| Associated microRNA: |
miR-338 |
| Biological function: |
Promotes HCC progression, tumor growth, cell viability, and glycolysis; inhibits apoptosis. |
| Molecular mechanism: |
Exosomal circFBLIM1 acts as a competing endogenous RNA sponge for miR-338, thereby upregulating LRP6 and promoting HCC progression and glycolysis. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot |
| Clinical significance: |
The circFBLIM1/miR-338/LRP6 axis may provide promising therapeutic targets or a new therapeutic approach for HCC treatment. |
| Description: |
Exosomal circFBLIM1 is up-regulated in HCC serum exosomes and HCC cells. It promotes HCC cell viability, tumor growth, and glycolysis while suppressing apoptosis, mainly by sponging miR-338 to upregulate LRP6. The circFBLIM1/miR-338/LRP6 axis is proposed as a potential therapeutic target for HCC. |
| Confidence score: |
0.7032 |