circRNA basic information
circBase ID: hsa_circ_0006220
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:35800605-35800763:+
Genomic location(hg38): chr17:37440504-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LAC tissues; adjacent non-cancerous tissues; adjacent normal tissue
Cell lines:

H1299; H1975
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KIF2C, KIF18B, MELK, BIRC5, PLK1, CKAP2L
Associated microRNA: miR-520f, miR-1261, miR-1270, miR-620, miR-188-3p, miR-516b, miR-940, miR-661
Biological function: Promotes proliferation, migration and invasion in LAC cells.
Molecular mechanism: May act as a miRNA sponge within a circRNA-miRNA-mRNA (ceRNA) network to regulate hub genes (e.g., KIF2C).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay
Clinical significance:

Higher expression level indicates poorer prognosis in patients with LAC.
Description:

hsa_circ_0006220 is up-regulated in lung adenocarcinoma tissues, and higher expression is associated with poorer prognosis. Knockdown suppresses LAC cell proliferation, migration, and invasion, and bioinformatic networks suggest a potential ceRNA role involving miRNAs and hub genes (e.g., miR-520f/KIF2C).
Confidence score:

0.7842
Other information
Title:

Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study.

Journal: Oncology letters
Published: 2022
PubMed ID: 35340554
Study type:

combined biological and clinical study
Data availability: GSE101586; TCGA; GEPIA
Code availability: -