circRNA basic information
circBase ID: hsa_circ_0057105
Name: hsa_circ_PDK1
Synonym: circ_0057105
Host Gene: PDK1
Genomic location(hg19): chr2:173433468-173460751:+
Genomic location(hg38): chr2:172568740-172596023:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0003210
MONDO name: intrahepatic cholangiocarcinoma
Disease details: intrahepatic cholangiocarcinoma
Disease DO ID:
 4928
Disease MeSH ID:
 -
Disease NCIt ID:
 C35417
Disease ICD11 ID:
 1253728223; 387909164
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ICC tissues; matched adjacent normal tissues; adjacent normal tissues; mouse lung tissues; mouse tumor tissues
Cell lines:

HiBEC; QBC-939; HuCCT1; RBE; HCCC9810; HEK293
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: AGO2, MDM2, p53, P53, ubiquitin, Ub
Associated microRNA: miR-1290
Biological function: Promotes ICC cell proliferation, migration, invasion, tumor growth, and metastasis; acts as an oncogenic circRNA and therapeutic target.
Molecular mechanism: circ_0057105 functions as a ceRNA sponge for miR-1290, derepresses MDM2 expression, enhances MDM2-mediated P53 ubiquitination and degradation, and inhibits the P53 signaling pathway.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); p53 signaling (inhibits); ceRNA regulation (other); ubiquitination (promotes)
Detected method:
Q
H
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; FISH / smFISH; IHC (Immunohistochemistry); Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Elevated circ_0057105 expression correlates with microvascular invasion, advanced TNM stage, shorter OS and DFS, and unfavorable prognosis; it is proposed as a prognostic biomarker and therapeutic target.
Description:

circ_0057105 is a PDK1-derived cytoplasmic circRNA that is significantly upregulated in ICC and is associated with aggressive clinicopathological features and poor survival. It promotes ICC proliferation, migration, invasion, tumor growth, and metastasis by sponging miR-1290 to upregulate MDM2, thereby enhancing P53 ubiquitination/degradation and inhibiting the P53 signaling pathway. LNP-mediated si-circ_0057105 delivery suppresses tumor growth in vivo, supporting circ_0057105 as a prognostic biomarker and therapeutic target.
Confidence score:

0.9033
Other information
Title:

Circ_0057105 promotes intrahepatic cholangiocarcinoma progression by sponging miR-1290 and regulating the MDM2/P53 pathway.

Journal: Cellular signalling
Published: 2026
PubMed ID: 41748046
Study type:

combined biological and clinical study
Data availability: Supplementary Table S1; Supplementary Table S2; Supplementary Table S3; Supplementary Table S4; Supplementary information files; https://doi.org/10.1016/j.cellsig.2026.112447
Code availability: -