| Expression pattern: |
DN |
| Associated gene: |
2,003 unique downstream targets, ubiquitin-mediated proteolysis, MAPK signaling pathway, Hippo signaling pathway, Wnt signaling pathway, ErbB signaling pathway |
| Associated microRNA: |
miR-5683, miR-6504-3p, miR-10399-5p, miR-6839-5p, miR-449c-5p, miR-34b-5p, miR-4642, miR-378j, miR-2682-5p, miR-10395-3p |
| Biological function: |
May participate in TNBC radiation response through suppression of chromatin remodeling and protein degradation pathways during DNA repair. |
| Molecular mechanism: |
Predicted ceRNA mechanism and enrichment in ubiquitin-mediated proteolysis, MAPK, Hippo, Wnt and ErbB signaling pathways. |
| Biological pathway or process: |
ubiquitination (inhibits); MAPK (other); Hippo/YAP (other); Wnt/beta-catenin (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Bioinformatics Analysis |
| Clinical significance: |
Potential radiation sensitivity biomarker and therapeutic target to improve TNBC treatment efficacy. |
| Description: |
circATAD2 is consistently suppressed after irradiation in TNBC cell lines. Its predicted miRNA targets and downstream pathway enrichment suggest involvement in ubiquitin-mediated proteolysis and multiple signaling pathways relevant to radiation response. |
| Confidence score: |
0.329 |