circRNA basic information
circBase ID: -
Name: hsa_circ_RBM33
Synonym: circRBM33
Host Gene: RBM33
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004994
MONDO name: cardiomyopathy
Disease details: cardiomyopathy
Disease DO ID:
 0050700
Disease MeSH ID:
 D009202
Disease NCIt ID:
 C34830
Disease ICD11 ID:
 282225286
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human heart biopsies
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: RBM33 transcripts
Associated microRNA: -
Biological function: Circular-to-linear ratio (CLR) of circRBM33 is increased in both DCM and HCM compared to HTX, mainly due to decreased linear RBM33 transcripts.
Molecular mechanism: Deregulation is described at the circular-to-linear ratio level and attributed mainly to reduced linear RBM33 expression.
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

The CLR of circRBM33 is increased in both DCM and HCM compared to HTX controls in this pilot patient cohort.
Description:

In human heart biopsy samples, circRBM33 shows an increased circular-to-linear ratio in both dilated and hypertrophic cardiomyopathy compared with HTX controls, attributed mainly to reduced linear RBM33 transcript levels. The study does not define a downstream mechanistic axis for circRBM33 in cardiomyopathy.
Confidence score:

0.348
Other information
Title:

Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq.

Journal: Frontiers in molecular biosciences
Published: 2022
PubMed ID: 35755822
Study type:

clinical study
Data availability: BioProject PRJNA825392
Code availability: -