| Expression pattern: |
UP |
| Associated gene: |
2,527 unique genes, MAPK signaling pathway, Ras signaling pathway, Proteoglycans in cancer pathway, cGMP-PKG signaling pathway, axon guidance, cholinergic synapse pathways |
| Associated microRNA: |
miR-22-5p, miR-6825-5p, miR-6072, miR-4677-5p, miR-6891-3p, miR-6780a-3p, miR-4494, miR-6728-3p, miR-1226-3p, miR-502-5p |
| Biological function: |
May act as a component of universal DNA damage response and link damage response systems to growth signaling, potentially influencing treatment sensitivity. |
| Molecular mechanism: |
Predicted ceRNA mechanism through miRNA binding, with enrichment of MAPK and Ras signaling and growth-control pathways. |
| Biological pathway or process: |
MAPK (other); proliferation (other); drug resistance (other); radioresistance (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Bioinformatics Analysis |
| Clinical significance: |
Potential radiation sensitivity biomarker and therapeutic target to improve TNBC treatment efficacy. |
| Description: |
circFBXW7 is progressively induced after irradiation in TNBC cells. Predicted miRNA interactions and pathway enrichment suggest that it may connect DNA damage response to MAPK/Ras growth signaling and may affect radiation treatment sensitivity. |
| Confidence score: |
0.329 |