circRNA basic information
circBase ID: -
Name: hsa_circ_TP53
Synonym: circTP53
Host Gene: TP53
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

BT-20; MDA-MB-231; MDA-MB-468
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: 4,001 unique target genes, p53 pathway, FOXO signaling pathway, AMPK signaling pathway, mRNA surveillance pathway, signaling pathways regulating pluripotency of stem cells, Polycomb repressive complex pathway
Associated microRNA: miR-1305, miR-4659a/b-3p, miR-466, miR-4632-3p, miR-4643, miR-374a-3p, miR-7160-5p, miR-3118, miR-134-5p, miR-199b-5p
Biological function: May coordinate stress response pathways and modulate p53-mediated DNA damage response, survival, repair, and treatment resistance after ionizing radiation.
Molecular mechanism: Predicted competing endogenous RNA mechanism through miRNA binding; pathway enrichment suggests involvement in p53, FOXO and AMPK signaling.
Biological pathway or process:

p53 signaling (other); AMPK (other); apoptosis (other); drug resistance (other); radioresistance (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential radiation sensitivity biomarker and therapeutic target to improve TNBC treatment efficacy.
Description:

circTP53 is up-regulated in irradiated TNBC cell lines in a dose-dependent manner and its expression parallels p53 phosphorylation. Bioinformatics analysis suggests that it may function as a ceRNA involved in p53, FOXO and AMPK signaling, with potential value as a radiosensitivity biomarker.
Confidence score:

0.4375
Other information
Title:

Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Published: 2026
PubMed ID: 41746541
Study type:

biological research / bioinformatics study
Data availability: All data produced in the current study are available from the corresponding author upon reasonable request; supplementary material available at https://doi.org/10.1007/s12094-026-04280-1
Code availability: -