circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: circSMARCA5
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; tumor tissues; heart; spleen; lung; kidney
Cell lines:

T24; RT4; PC3
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circSMARCA5 was evaluated as a bladder cancer-associated biomarker detectable in serum matrices, cancer cell lines, and xenograft tumor tissues; tumor tissues showed higher circSMARCA5-associated fluorescence signals than non-tumor organs and healthy tissues.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; In Vivo Animal Model
Clinical significance:

bladder cancer-associated biomarker for sensitive multiplex circRNA detection
Description:

This study used circSMARCA5 as one of two bladder cancer-associated circRNA biomarkers to validate a modular fluorescent RNA aptamer biosensor. The platform detected circSMARCA5 with femtomolar sensitivity, distinguished target circRNA from related nucleic acids, and showed higher tumor-tissue signals in a T24 cell line-derived xenograft model.
Confidence score:

0.2586
Other information
Title:

Structure-guided engineering of modular RNA aptamer biosensors for one-pot, multiplex detection of CircRNAs.

Journal: International journal of biological macromolecules
Published: 2026
PubMed ID: 41730444
Study type:

biological research / biosensor method development
Data availability: Data will be made available on request.
Code availability: -