circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; paracancerous tissues
Cell lines:

RWPE-1; 22RV1; PC-3; DU145; LNCaP
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ADAM17
Associated microRNA: miRNA-338-3p
Biological function: promotes proliferation and invasion of prostate cancer cells
Molecular mechanism: circHIPK3 acts as a miRNA sponge for miRNA-338-3p to regulate ADAM17 expression (ceRNA mechanism)
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

In prostate cancer, circHIPK3 is up-regulated and promotes proliferation and invasion. Mechanistically, it sponges miRNA-338-3p to relieve repression of ADAM17, thereby accelerating malignant progression.
Confidence score:

0.6479
Other information
Title:

CircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31118688
Study type:

combined biological and clinical study
Data availability: -
Code availability: -