circRNA basic information
circBase ID: hsa_circ_0000228
Name: hsa_circ_ZEB1
Synonym: circZEB1
Host Gene: ZEB1
Genomic location(hg19): chr10:31661946-31676195:+
Genomic location(hg38): chr10:31373017-31387266:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018881
MONDO name: myelodysplastic syndrome
Disease details: myelodysplastic neoplasms
Disease DO ID:
 0050908
Disease MeSH ID:
 -
Disease NCIt ID:
 C3247
Disease ICD11 ID:
 -
Disease OMIM ID:
 614286
Species: Human
Species details: Homo sapiens
Tissue specimen:

CD34+ bone marrow cells; CD34+ HSPCs; bone marrow aspirate
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with SF3B1-mutated MDS and poorer overall survival; potential biomarker of mutational signature and patient outcome.
Molecular mechanism: circZEB1 expression is associated with mutant SF3B1 and presumed alterations in splicing behavior; functional impact was not experimentally assessed.
Biological pathway or process:

other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circZEB1 levels in SF3B1-mutated MDS were associated with poorer overall survival at 5 years.
Description:

circZEB1 (hsa_circ_0000228) is upregulated in MDS, particularly in cases with SF3B1 mutations. In the independent ring sideroblast cohort, high circZEB1 expression among SF3B1-mutated patients was associated with poorer overall survival, suggesting clinical biomarker potential rather than a mechanistically validated functional role.
Confidence score:

0.5121
Other information
Title:

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression.

Journal: Molecular oncology
Published: 2026
PubMed ID: 41711097
Study type:

combined bioinformatics and clinical study
Data availability: Restricted-access raw RNA sequencing data available by application to kirsten. groenbaek@regionh.dk; Swedish National Data Service repository https://doi.org/10.48723/zt59-8x04
Code availability: https://github.com/ncrnalab/pyutils