| Expression pattern: |
DN |
| Associated gene: |
coronary artery stenosis grade / CAS grade |
| Associated microRNA: |
- |
| Biological function: |
Auxiliary diagnostic biomarker for IHD-related SCD; indicates ischemic myocardial damage (decreased expression). |
| Molecular mechanism: |
Negative association with coronary artery stenosis grade (biomarker association). |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
Downregulated circNFIX distinguishes IHD-related SCD cases from controls (ROC AUC 0.868 overall) and is negatively correlated with coronary artery stenosis grade; combination with circSLC8A1 improves discrimination. |
| Description: |
circNFIX is down-regulated in myocardium from IHD-related SCD autopsy cases (both MI and non-MI) and shows diagnostic value by ROC analysis. Its expression is negatively correlated with coronary artery stenosis grade, supporting its use as an auxiliary indicator of ischemic myocardial damage severity. |
| Confidence score: |
0.6888 |