| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Serves as an up-regulated breast cancer diagnostic and staging biomarker measured by the nanodevice and qRT-PCR; combined with circMTO1 to distinguish breast cancer patients from healthy counterparts and stages. |
| Molecular mechanism: |
No disease molecular mechanism was tested; the study used BSJ-specific capture probe hybridization, DSN-powered 3D-DNA walking, and RCT-based fluorescent aptamer signal amplification to detect circCDYL. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Up-regulated in breast cancer tissues; used with circMTO1 as a diagnostic and staging biomarker with high accuracy across early and advanced breast cancer stages. |
| Description: |
circCDYL is a human CDYL-derived circRNA that was measured in breast cancer cells and clinical breast tissues. The study found circCDYL up-regulation in breast cancer tissues and used it together with circMTO1 as a diagnostic and staging biomarker, validated by the authors' nanodevice and qRT-PCR. |
| Confidence score: |
0.559 |