| Expression pattern: |
UP |
| Associated gene: |
PIM1 |
| Associated microRNA: |
miR-370 |
| Biological function: |
promotes OS cell proliferation, migration and invasion |
| Molecular mechanism: |
ceRNA sponging of miR-370 leading to upregulation of PIM1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay |
| Clinical significance: |
potential biomarkers for early screening, diagnosis, and monitoring of treatment progression for osteosarcoma |
| Description: |
circITGA7 is up-regulated in osteosarcoma tissues and OS cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, circITGA7 functions as a ceRNA to sponge miR-370, thereby relieving repression of PIM1 and driving OS progression. |
| Confidence score: |
0.6369 |