circRNA basic information
circBase ID: -
Name: hsa_circ_ACAP2
Synonym: -
Host Gene: ACAP2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005072
MONDO name: neuroblastoma
Disease details: neuroblastoma
Disease DO ID:
 769
Disease MeSH ID:
 D009447
Disease NCIt ID:
 C3270
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

neuroblastoma tissues; adjacent noncancerous tissues; matched non-tumorous neuronal tissues
Cell lines:

IMR-32; SK-N-SH; NHA
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: hexokinase 2 / HK2
Associated microRNA: miR-143-3p
Biological function: promotes migration, invasion, and glycolysis; inhibits apoptosis
Molecular mechanism: ceRNA sponging of miR-143-3p leading to increased HK2 expression
Biological pathway or process:

glycolysis (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Wound Healing Assay; Transwell Assay; MTT; Annexin V/PI Flow Cytometry
Clinical significance:

-
Description:

circRNA-ACAP2 is up-regulated in neuroblastoma tissues and cell lines and promotes migration, invasion and glycolysis while inhibiting apoptosis. Mechanistically, it sponges miR-143-3p to relieve repression of HK2, forming an ACAP2/miR-143-3p/HK2 axis that drives oncogenic phenotypes in vitro.
Confidence score:

0.7032
Other information
Title:

CircRNA-ACAP2 contributes to the invasion, migration, and anti-apoptosis of neuroblastoma cells through targeting the miRNA-143-3p-hexokinase 2 axis.

Journal: Translational pediatrics
Published: 2021
PubMed ID: 35070838
Study type:

combined biological and clinical study
Data availability: Available at https://dx.doi.org/10.21037/tp-21-527
Code availability: -