circRNA basic information
circBase ID: hsa_circ_0069382
Name: hsa_circ_TBC1D19
Synonym: hsa_circTBC1D19_011
Host Gene: TBC1D19
Genomic location(hg19): chr4:26622234-26685371:+
Genomic location(hg38): chr4:26620612-26683749:+
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; paraneoplastic tissues; adjacent tissues
Cell lines:

GES-1; MKN-28; SGC-7901; MGC-803; MKN-45; AGS; HGC-27; HEK 293 T; HGC-27; AGS
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: BTG2, FAK
Associated microRNA: miR-15a-5p
Biological function: inhibits proliferation, invasion, and migration of gastric cancer cells; inhibits tumor growth in vivo
Molecular mechanism: ceRNA mechanism: hsa_circ_0069382 sponges miR-15a-5p to upregulate BTG2 and downregulate FAK (BTG2/FAK axis)
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

potential diagnostic biomarker and therapeutic target for gastric cancer
Description:

hsa_circ_0069382 is down-regulated in gastric cancer tissues/cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration and invasion and reduces xenograft tumor growth, mainly by sponging miR-15a-5p to modulate the BTG2/FAK axis.
Confidence score:

0.7897
Other information
Title:

A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression.

Journal: Cancer cell international
Published: 2023
PubMed ID: 36841760
Study type:

combined biological and clinical study
Data availability: The original contributions presented in the study are included in the article/Additional file Material.
Code availability: -